Cell therapies for inflammatory bowel diseases
نویسندگان
چکیده
منابع مشابه
Cell therapies for inflammatory bowel diseases.
Present therapy of inflammatory bowel diseases (IBDs) is aimed at relieving inf lammation and treating signs and symptoms. Therapy consists of nonspecific anti-inflammatory agents, such as 5-aminosalicylic acid, glucocorticoids, immunomodulators and anti-TNF therapy. The goals of therapy should include the induction and maintenance of remission and an attempt to heal the mucosa with the ultimat...
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Crohn's disease and ulcerative colitis are chronic disabling inflammatory bowel diseases (IBDs). Although the causes of IBD are unknown, defects in innate and adaptive immune pathways have been identified and biological therapies that target key molecules have been designed. Infliximab, a chimeric immunoglobulin (Ig)G1 monoclonal antibody to tumor necrosis factor, dramatically improved treatmen...
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Gut inflammation occurring in patients with IBDs (inflammatory bowel diseases) is associated with exaggerated and poorly controlled T-cell-mediated immune responses, which are directed against normal components of the gut flora. T-cells accumulate in the inflamed gut of IBD patients as a result of multiple mechanisms, including enhanced recruitment of cells from the bloodstream, sustained cell ...
متن کاملNew and emerging therapies for inflammatory bowel diseases.
The inflammatory bowel diseases have undergone an explosion of discovery in the last 10 years. The overwhelming focus of this has been in genetics and immune mechanisms of disease. While the former has provided critical information on predisposing factors, the latter has resulted in a panoply of novel immune-based therapies and technologies. These range from an improved approach to the use of c...
متن کاملInflammatory bowel diseases: emerging therapies and promising molecular targets.
An enormous amount of pathoetiologic information continues to accrue from animal models of inflammatory bowel disease and study of the gut microbiome that is providing expanded insight into the causes and mechanisms of inflammatory bowel diseases. This knowledge is being translated into new therapeutics that are being tested in Crohn's and ulcerative colitis patients with an aim to enhance trea...
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ژورنال
عنوان ژورنال: Expert Review of Gastroenterology & Hepatology
سال: 2009
ISSN: 1747-4124,1747-4132
DOI: 10.1586/egh.09.26